In this example, data include numbers (both as scalar and array), a graph, and the output of the error cluster. When the VI runs, the “Indicator” outputs on the right of the panel are populated with output data. Included here are number inputs, a file path box, and a general error propagation cluster. Input data are passed through “Controls” which are shown to the left. The top panel (A) shows the front panel of the VI. In Figure 1 b, VIs such as Mean.vi, Median Filter.vi, and Write to Spreadsheet File.vi are being used as sub-Vis.įigure 1. Figure 1 a shows the front panel of an example VI and Figure 1 b the block diagram or the code for the VI. Each function or routine is stored as a virtual instrument (VI) having three main components: the front panel which is essentially a form containing inputs and controls and can be displayed at run time, a block diagram where the code is edited and represented graphically, and a connector pane which serves as an interface to the VI when it is imbedded as a sub-VI. 1 Program execution follows connector wires linking processing nodes together. LabVIEW implements a dataflow paradigm in which the code is not written, but rather drawn or represented graphically similar to a flowchart diagram ( Figure 1 ). LabVIEW, which stands for Laboratory Virtual Instrumentation Engineering Workbench is a graphical programming language first released in 1986 by National Instruments (Austin, TX). The platform is supported by a central Oracle database and can run either statically or dynamically scheduled processes. This application suite described in detail below, enables our end users to create and manage their own process models (assay scripts) in a common modeling environment, to use these process models on any automation system with the required devices, and allows easy and rapid device reconfiguration. To maximize platform consistency and modularity, each of our 10 automated platforms is controlled by a common, distributed application suite that we developed using National Instruments (NI) LabVIEW. This has given us the ability to integrate the most appropriate hardware and software solutions regardless of whether they are purchased from a vendor or engineered de novo, and hence we can rapidly modify systems as assay requirements change. To create the most flexible, high performance, and cost-effective systems, we have taken the approach of building our own systems in-house. Each in-house integrated system is designed around a robotic arm and contains an optimal set of plate-processing peripherals (such as pipetting devices, plate readers, and carousels) depending on its intended range of use. For example, we have several platforms for biochemical screening, systems for live cell processing, automated microscopy systems, and an automated compound storage and retrieval system. ![]() The requirements for processing these numbers and diversity of assays have mandated deployment of multiple integrated automation systems. The infrastructure provides capacity to screen millions of compounds per year in tests ranging from multiprotein biochemical assays that mimic biological function to automated image-based cellular assays with phenotypic readouts. ![]() Since inception we have developed a robust technology infrastructure to support our drug discovery efforts. Cytokinetics is a biopharmaceutical company focused on the discovery of small molecule therapeutics that target the cytoskeleton.
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